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TCNJ Chemistry Department Lecture Series: Feb. 3

Beyond Activity Measurements: Leveraging Biophysics and Structure for Hit Identification and Prioritization
Dr. William Metzler, Associate Director, Lead Development, Bristol-Myers-Squibb, Emeritus
Wednesday, February 3rd, 2016, 11 am – 12 pm, SCC121
The emergence of fragment-based screening as a vehicle for identifying novel chemical leads is challenging the current paradigm for lead optimization.  When dealing with molecules with the chemical simplicity of fragments, one can no longer rely solely on potency.  And while ligand efficiency (the binding energy per heavy atom) is becoming increasingly popular for evaluating the quality of hits, one often requires a more detailed understanding of the molecular interactions leading to the observed potency.   This presentation will describe our efforts to create a “biophysical toolbox” for evaluating and prioritizing hits.  The toolbox contains methods for examining a compound’s propensity to aggregate, its specificity of binding, assessment of reversibility, and thermodynamic properties.  Combined with the mapping of receptor:ligand interactions at the molecular level that is afforded by structural studies, the approach provides additional information for selecting hits that are the most likely to progress at a critical point in early-phase decision, thereby facilitating the delivery of high quality leads.

TCNJ Chemistry Department Lecture Series: Nov. 18

Breaking strong bonds and recovering rare earths: Adventures in sustainable chemistry Marion Emmert – Assistant Professor, Worcester Polytechnic Institute Wednesday, November 18th, 2015, 11 am – 12 pm, SCC121 Catalysis is one of the most powerful tools of green chemistry, enabling reactions with lower energy consumption and providing new pathways for bond formations. In particular, catalytically… Continue Reading

TCNJ-Novo Nordisk Colloquium: Oct. 20

Dr. Todd Hobbs and Dr. Henriette Mersebach, Novo Nordisk in North America How a Drug is Born Tuesday, October 20th, 2015, 4 – 5 pm, SCP101 The first in a series of lectures to highlight the recent partnership between Novo Nordisk and TCNJ, this lecture will take the audience through the many steps required in… Continue Reading