“Investigations of Chemical Signaling in Bacterial Pathogens“
Dr. Lark J. Perez
Rowan University
Department of Chemistry and Biochemistry
Date: Wednesday, November 1st
Time: 11:00 AM
Room: Chemistry C121
ABSTRACT
Bacterial and mammalian cells carefully regulate cellular processes using chemical signaling. In mammalian cells, one example of chemical signaling regulation is in the resolution of inflammation triggered by the small-molecule Lipoxin A4. Bacterial pathogens such as Pseudomonas aeruginosa regulate virulence factor expression and biofilm formation through their own specialized chemical signaling pathways using a process commonly known as quorum sensing (QS). I will describe our discovery of the sensing of the mammalian signaling molecule Lipoxin A4 by P. aeruginosa and our investigations into the inhibition of QS-regulated virulence in this bacteria.
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Chemistry Department Lecture Series – Dr. Lark J. Perez