The College of New Jersey Logo

Apply     Visit     Give     |     Alumni     Parents     Offices     TCNJ Today     Three Bar Menu

Events Archive

TCNJ Chemistry Department Lecture Series: Feb. 3

Beyond Activity Measurements: Leveraging Biophysics and Structure for Hit Identification and Prioritization
Dr. William Metzler, Associate Director, Lead Development, Bristol-Myers-Squibb, Emeritus
Wednesday, February 3rd, 2016, 11 am – 12 pm, SCC121
The emergence of fragment-based screening as a vehicle for identifying novel chemical leads is challenging the current paradigm for lead optimization.  When dealing with molecules with the chemical simplicity of fragments, one can no longer rely solely on potency.  And while ligand efficiency (the binding energy per heavy atom) is becoming increasingly popular for evaluating the quality of hits, one often requires a more detailed understanding of the molecular interactions leading to the observed potency.   This presentation will describe our efforts to create a “biophysical toolbox” for evaluating and prioritizing hits.  The toolbox contains methods for examining a compound’s propensity to aggregate, its specificity of binding, assessment of reversibility, and thermodynamic properties.  Combined with the mapping of receptor:ligand interactions at the molecular level that is afforded by structural studies, the approach provides additional information for selecting hits that are the most likely to progress at a critical point in early-phase decision, thereby facilitating the delivery of high quality leads.

TCNJ Chemistry Department Lecture Series: Nov. 18

Breaking strong bonds and recovering rare earths: Adventures in sustainable chemistry Marion Emmert – Assistant Professor, Worcester Polytechnic Institute Wednesday, November 18th, 2015, 11 am – 12 pm, SCC121 Catalysis is one of the most powerful tools of green chemistry, enabling reactions with lower energy consumption and providing new pathways for bond formations. In particular, catalytically… Continue Reading

TCNJ Homecoming Event

TCNJ undergraduates, alumni, and faculty gathered on Saturday, October 24th at the Department of Chemistry tent at the 2015 TCNJ Homecoming. Continue Reading

TCNJ Chemistry Department Lecture Series: Oct. 21

The influence of Lewis acids on organometallic chemistry Professor Graham Dobereiner, Department of Chemistry, Temple University Wednesday, October 21st, 2015, 11 am – 12 pm, SCC121 Bimetallic catalysis is an emerging research area. Novel bond activations are made possible through the collective action of two metal centers. In our group, the interactions of organometallic complexes with… Continue Reading

TCNJ Chemistry Department Lecture Series: Oct. 7

Jessica Molek, Scientific Manager, Downstream Process Development, BioPharm R&D, GlaxoSmithKline Wednesday, October 7th, 2015, 11am – 12pm SCC121 Industrial production of a monoclonal antibody: Perspectives from biopharmaceutical process development Monoclonal antibodies (MAbs) are an important and growing class of therapeutic proteins. The production of these molecules is no longer limited to specialized start-ups but is… Continue Reading

Philadelphia Inorganic Colloquium: Sept. 12

The second Philadelphia Inorganic Colloquium (PIC-2) will be held Saturday, September 12, 2015 from 10 am – 4:30pm. All local scientists are welcome, and there is no registration fee. Just like PIC-1, the meeting will be a venue for sharing research in inorganic chemistry, and opportunity for networking with area scientists. The meeting features four seminars as… Continue Reading

Goodbye to the Bridge

Last week marked the end of a chapter for the Science Complex and the beginning of a new phase for Chemistry.  As part of Phase I of the STEM Complex Construction, the structure– fondly referred to as “the bridge”– that connected Chemistry and Biology buildings was torn down to make room for a new STEM addition.… Continue Reading

TCNJ Chemistry Department Lecture Series

Professor Jessica Hoover, Department of Chemistry, West Virginia University, Wednesday, September 16, 2015, 11 am – 12 pm, SCC121 Copper-Catalyzed Oxidative Decarboxylative Coupling Reactions Decarboxylative coupling reactions are emerging as an efficient route to access a diverse array of substituted arenes from inexpensive and readily available precursors. Unfortunately, most methods require pre-functionalized aryl halide coupling… Continue Reading

Symposium in Honor of Professor Maurice Brookhart

On June 20, 2015, Dr. O’Connor hosted a retirement symposium to honor the work of her PhD advisor, Professor Maurice Brookhart. Dr. Brookhart is the William R. Kenan, Jr. Professor of Chemistry in the Department of Chemistry at the University of North Carolina and is internationally known for his work in the area of organometallic… Continue Reading

Top