Professor Jessica Hoover, Department of Chemistry, West Virginia University, Wednesday, September 16, 2015, 11 am – 12 pm, SCC121
Copper-Catalyzed Oxidative Decarboxylative Coupling Reactions
Decarboxylative coupling reactions are emerging as an efficient route to access a diverse array of substituted arenes from inexpensive and readily available precursors. Unfortunately, most methods require pre-functionalized aryl halide coupling partners. An oxidative transformation enabling the direct decarboxylative coupling with an arene C-H bond is an attractive alternative, but current methodologies suffer limitations of substrate scope. Copper catalysts offer an opportunity to overcome these challenges, yet there are limited examples of a Cu-catalyzed transformation of this type.
This talk will focus on our recently developed copper-catalyzed oxidative decarboxylative C-H arylation reaction to generate biaryl products. Recent work to explore the reaction mechanism and understand the substrate limitations will also be presented.